You Don't Know Jack is available on CD-Rom, yes. There are even several varieties of the game: the original, XL, Volume 2, Sports, and Movies. The net version, which comes in "regular" and "sports" editions, requires the download of special client software, which takes about 20 minutes to download at 28.8k. They also have a few distinct differences from the CD-Rom games: The games are shorter (15 questions versus the full-length 21 questions), the "gibberish" questions occur at the same question each game, there are none of the "unusual" question types (e.g. "Fiber Optic Field Trip," "Celebrity Collect Call"), there are commercials every three or four questions, and you can win real prizes for playing the game.
As much as I enjoyed playing it when I originally wrote this review (and would still recommend it to people), I don't play it that much anymore, either the netshow or the CD-Rom. What turned me off most with the netshow was the "shortening" of the game and the increase in the number of commercials. I think the other reason I got tired of playing it was that I finally went out and bought XXL (XL + Volume 2). But I just got tired of playing it, though when I do play it, it is quite fun. The net show is a good way to get your feet wet with Jack. After you like it, go buy it on CD-Rom. ;-)
You've gotta at least try this, even if you're not into trivia games!